The so-called Saddleridge Fire started Thursday night around 9:00 p.m. local time along the northern rim of the San Fernando Valley and nearly immediately exploded from 60 acres to over 4,000 acres (1,619 hectares) overnight - jumping across the 210 and 5 freeways.
In Los Angeles, a man went into cardiac arrest and died at the scene of a raging wildfire that broke out late Thursday.
A blaze also ripped through a mobile home park in Calimesa, a city about 65 miles (104km) east of Los Angeles, destroying dozens of residences.
"A moderate to strong Santa Ana wind event will continue to bring risky fire weather conditions to most of Los Angeles and Ventura Counties through late Friday afternoon", NWS said in its latest alert.
The Saddleridge Fire Map is now at 4700 acres and 0% containment, and still growing.
Many schools and universities were also closed in northern parts of the state as people stocked up on gasoline, water, batteries and other basics, with frustration mounting at the blackouts condemned by some as "third world".
He says his mother said she was getting her purse and getting out.
The moon shines through smoke over a hillside of embers left by the Saddleridge Fire in Porter Ranch on October 11.
Approximately 25 homes and one commercial structure have been destroyed.
That outbreak, dubbed the Sandalwood fire after a local landmark, was 10% contained as of Thursday night.
It started when the load on a garbage truck caught on fire and spread to vegetation, Capt. Fernando Herrera of Cal Fire Riverside told CNN affiliate KABC. "It started just eating up vegetation as fast as the eye can see", he said.
For those in evacuation areas, there are a few shelter options.
For days, California utility companies have been preemptively cutting off power out of fear that high wind gusts could blow power lines into trees, sparking risky fires.
CORRECTION: An earlier version of this story misspelled the name of Los Angeles Police Chief Michel Moore, and misidentified the agency he leads.