But over a year on, little progress has been made under Ole Gunnar Solskjaer.
The Germans side are unbeaten in 2019/20 as they chase down a first-ever Premier League title.
Liverpool fans hope that this year will be the one that will put an end to their agony during the last 30 years.
The legendary Norwegian has managed to get a couple of big game results but lately, the magic has seemed to fade, in particular during the recent loss to Arsenal.
"Liverpool is obviously the natural enemy of some clubs; we have more natural enemies than other clubs have, probably because of our history and how successful the club was", he said, as quoted by FourFourTwo.
"But it is important that we can fight every year for it and that is all I need".
Under Ferguson, United won 13 English titles- a hegemony which Klopp does not think is feasible in the contemporary. At such rate, the Reds are set to grab the league by March and this fact has certainly irked Manchester United fans.
Much simpler to say that Pogba appears to do whatever he wants, which tells you all need to know about the kind of control that United assert over their highest paid employee, and by extension the club itself.
Klopp, 52, has been the team's manager since 2015.
So, in terms of the pre-match motivation to get that one minor slip right and also get one over their rivals, Jurgen Klopp's men will be up for it.
"It is now more probable that the various other clubs will certainly contend for various points due to the fact that of the economic power of a great deal of groups".
Mauricio Pochettino was United's primary target when Mourinho was sacked just over a year ago, but the Argentine was contracted to Tottenham at the time.
United, despite their topsy turvy form this season, have a unique record of being the only club which Liverpool has failed to take all three points from.